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Manchester United's Federico Macheda, Newcastle United's Nile Ranger and Walsall's Manny Smith have all been charged by the Football Association for alleged homophobic comments on Twitter.
The players are alleged to have acted in a way which was improper and/or brought the game into disrepute.
Each has until 1600 GMT on Wednesday 29 February to respond to the charges.
West Ham's Ravel Morrison and ex-Leicester player Michael Ball have recently been fined for similar cases.
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FA launches anti-homophobia campaign
Morrison was fined £7,000 by the FA in February after he admitted a charge of using abusive and/or insulting words on Twitter, including a reference to a person's sexual orientation.
Ball, who also played for England, Manchester City and Everton, was fined £6,000 for tweeting about Coronation Street actor Anthony Cotton.
The FA launched a new six-year inclusion and anti-homophobia plan last Monday called 'Opening Doors and Joining In' where it outlined its aims to rid the game of prejudice.
Macheda, 20, is currently on loan at QPR, having joined the west London club in January.